Catharine Mielnik

I have a strong background in behavioural pharmacology using mouse models of neuropsychiatric disease and the applicable neuropsychopharmacology, biochemical, and molecular principles associated with this work. I am currently a Postdoctoral Fellow working on the pre-clinical validation of cannabinoid molecules in mouse models of psychiatric disease.


University of Toronto

Principal Faculty:


Principal Department/Program:

Pharmacology & Toxicology

Principal Hospital Appointment:



Ruth Ross

Key Publications:

1. Mielnik CA, Kit LC, Ramsey AJ, Salahpour A, Burnham WM, Ross RA. Cannabidiol, but not ?9-tetrahydrocannabinol, has strain and genotype specific effects in models of psychosis. Cannabis Cannabinoid Res. 2022 Sep 07 Accepted. 2. Mielnik CA, Binko MA, Chen Y, Funk AJ, Johansson EM, Intson K, Sivananthan N, Islam R, Milenkovic M, Horsfall W, Ross RA, Groc L, Salahpour A, McCullumsmith RE, Tripathy S, Lambe EK, Ramsey AJ.Consequences of NMDA receptor deficiency can be rescued in the adult brain. Mol Psychiatry. 2021 Jul;26(7):2929-2942. Epub 2020 Aug 17. 3. Mielnik CA, Lam VM, Ross RA. CB1 allosteric modulators and their therapeutic potential in CNS disorders.Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110163. Epub 2020 Nov 3. Review. 4. Mielnik CA, Sugamori KS, Finlay DB, Thorpe HHA, Schapira M, Sivananthan N, Li CK, Lam VM, Harrington S, Abdelrahman MH, Trembleau LA, McIntyre Burnham W, Khokhar JY, Salahpour A, Ramsey AJ, Glass M, Greig IR, Ross RA. A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models. Neuropsychopharmacology. 2021 Jan;46(2):413-422. Epub 2020 Oct 8. 5. Sullivan CR*, Mielnik CA*, O’Donovan SM, Funk AJ, Bentea E, DePasquale EA, Alganem K, Wen Z, Haroutunian V, Katsel P, Ramsey AJ, Meller J, McCullumsmith RE. Connectivity Analyses of Bioenergetic Changes in Schizophrenia: Identification of Novel Treatments. Mol Neurobiol. 2019 Jun;56(6):4492-4517. Epub 2018 Oct 18. *Co-first author: these authors contributed equally to this work