Gabapentin (also known as Neurontin) is clinically prescribed for the treatment of seizures, pain, and anxiety. While gabapentin is known to modulate voltage-gated calcium channels, some studies have suggested the effects of gabapentin are also dependent on GABAergic inhibition.

Conditioned pain modulation (CPM) is the phenomenon in which one painful stimulus (the conditioning stimulus) affects the pain perception of a second stimulus (the test stimulus) at a different site.