Defining and Predicting Pain Volatility in Users of the Manage My Pain App: Analysis Using Data Mining and Machine Learning Methods
The advent of technology and mobile health apps has transformed the way people monitor, manage, and communicate health-related information. For pain, “Manage My Pain” is a mobile health app used by thousands of individuals to measure and manage their pain.
Gabapentin increases expression of subunit-containing GABAA receptors
Gabapentin (also known as Neurontin) is clinically prescribed for the treatment of seizures, pain, and anxiety. While gabapentin is known to modulate voltage-gated calcium channels, some studies have suggested the effects of gabapentin are also dependent on GABAergic inhibition.
Conditioned pain modulation is not unidirectional: both hyper- and hypoalgesia can arise depending on the stimulus
Conditioned pain modulation (CPM) is the phenomenon in which one painful stimulus (the conditioning stimulus) affects the pain perception of a second stimulus (the test stimulus) at a different site.